Carbon dioxide (CO2) capture and storage (CCS) has the potential to offer large-scale mitigation of CO2 emissions from electric power. However, the nature and extent of its deployment will vary regionally depending not just on the characteristics of the geologic reservoir capacity but also on the major economic characteristics of the regional electric power system. Differences among electric power systems such as the current generating capacity mix, the demand for new capacity, the relative cost of fuels, and the electric load profile will be key drivers in determining the nature and extent of future CCS deployment by region. In this paper, we explore the potential deployment of CCS in power generation in three electricity market regions: the ECAR region in the Midwest, the SERC region in the Southeast, and the ERCOT region in Texas. We combine a detailed model of CO2 storage reservoir potential with an economic model of the physical and economic characteristics of the regional electric power system to advance an integrated understanding of the differences in deployment characteristics of a CCS system across these regions. These three regions are selected to span a range of conditions in terms of the electric power system and capacity mix as well as regional access to geologic CO2 storage reservoirs such as deep saline formations and depleted oil plays.